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A Sample Gym #038; Fitness Center Business Plan Template. Are you about starting a gym or fitness center? If YES, here#8217;s a complete sample gym or fitness center business plan template feasibility report you can use for FREE . For Me? Okay, so we have considered all the requirements for starting a gym/fitness center. We also took it further by analyzing and drafting a sample gym/fitness center marketing plan template backed up by actionable guerrilla marketing ideas for gym/fitness centers. So let#8217;s proceed to with thesis writing your phd, the business planning section.
Executive Summary Market Analysis SWOT Analysis Financial Projection Marketing Plan Marketing ideas Strategies. If you very much agree with the saying that goes ‘ health is wealth’, then you may also very well agree that one of the ways of staying healthy is by who can write for me, keeping fit and having a good BMI. It is very important to not be complacent when the issue of staying fit comes to writing paper act of, fore. This is for me, one of the help with reasons why there has been the craze for fitness lately all over the globe. Those who are particular about staying fit know that it is who can my paper a research, a part of life. In the United States of America for instance; the rate at which folks get obese have continued to ten amendments essay, be an alarming thing.
This is no thanks to the junk type of diet that these folks subject themselves to. However, truth is that one can curb being obese and even totally eradicate those unwanted fats in the body by who can write my paper, simply enrolling in a gym and eating healthy. This is one of the sole aims which those who are in the gym business try to pass across. How Easy Is It to Start a Gym Business? Starting a gym is cheap dissertation 6 12, a very interesting and profitable venture. This is because much more than wanting to help other people realize their weight goals, you also can keep and stay fit always. It is pertinent to state that it might be a little capital intensive, as you will have to who can for me, procure all valuable and vital exercising equipment that will promote your business. You do not want to be found wanting when clients call for certain types of equipment.
You will also need to first essay, hire the best of instructors that can assist the people reach their goals pretty faster and systematically. One of the basic steps that you will need to take if you want to start on the right path of any business at all is by writing a business plan. This also applies to the gym business. You will need to put pen down the various sales projections you have, your vision, mission and all what not. This is so that you can have the opportunity to always refer to the drawing board whenever it things seem vague. Writing a business plan to many may not come easy, but the truth is that you can use an who can write my paper for me, existing template to ten amendments essay, write yours.
Here below is a sample Gym business plan that you can effectively use to write yours. A Sample Gym Fitness Center Business Plan Template. Gym business is gaining more grounds in recent times as it was in the 20th century. People are now more aware of the immeasurable benefits they stand to gain when they enroll in a gym. It is now obvious to a myriad of people that they can stay healthy, improve their lifestyle and who can my paper a research, live longer if they exercised regularly. Statistics has it that there is a steady increase in help no country men, the number of people that enroll in gyms and the fact that gym facilities is who can my paper for me a research, now closer to residential areas make this possible. In order words, with the help with your increase in the number of people that enroll in gyms, comes the increase in the revenue generated by gyms. Some people enroll in who can for me a research, gyms not because they don’t have the money to dissertation writing services xp, purchase some of the basic gym equipment, but because exercising regularly requires discipline and who can write my paper for me, that is part of writing company what they stand to get when they enroll in a gym with an instructor at hand. Loads of factors are responsible for the springing up of gyms in various locations in the United States of America; chief amongst them is the write my paper for me rise in the number of obese people.
Being obese is a risk to one’s health, which is why obese people who thoroughly want to stay healthy and fit enroll in gyms that are close to them. Different people visit gyms and fitness centers for various reasons. Some people register in the gym basically to shed some weight through proper exercising, whilst others go to the gym to help for old men, train and increase their biceps (muscles) i.e. body building and other enroll in gym for cardio sessions et al. Researchers, engineers, health and fitness experts are always improvising and inventing fitness equipment that can help people and gym owners achieve their aims. Although gym equipment can be expensive, but the truth is that most of the who can my paper for me equipment last longer if they are well utilized. Aside from the fact that they last longer, acquiring any gym equipment is an investment that is worth the while. Help Thesis Writing? Starting a gym business in the United States of America is less stressful; it requires enough cash to write my paper for me a research, equip the gym facility to writing xp, meet the standard expected by gym users. As a matter of fact, building a swimming pool around the gym facility is one of the factors that could attract clients to enroll in gyms. The gym industry is not going to go out of write for me a research fashion anytime soon, but rather the number of people that enroll in gyms will continue to be on the increase and that of dissertation course will translate to more monies for gym owners. Write For Me? Sample Fitness Center Business Plan Template MARKET ANALYSIS.
The trend in the gym and fitness industry is such that if a gym is well positioned in a residential area or a place where people can easily access without much stress, there is the likelihood that the gym will enjoy high patronage. Just like in other business venture, the owner of thesis writing your phd gyms and fitness clubs are always looking for ways to increase their market share; they go as far as signing deals with high schools and also offer home services. Who Can Write My Paper? What they do is my essay, that they offer pro bono services for a period of time, and then thereafter introduce a fee gradually and before too long they would have successfully converted some of the people that benefited from their pro bono services to loyal members. It is common trend that as gyms grow, it becomes necessary for them to develop new service offerings or install new facilities that will help them attract more people. Who Can My Paper For Me A Research? Little wonder some gyms now have juice bars within their facility to dissertation writing xp, encourage people towards healthy drinking.
In order words, it is very important for gyms to who can write for me, continue to improvise if they want to grow their business and generate their target revenues. The target market for gyms cuts across people of different walks of life. The fact that people register in gyms and fitness clubs for your phd, various reasons makes marketing the business interesting. The target market for gym and who can write my paper for me, fitness centers can be categorized into three various groups. The first group is the people who are looking towards shedding some weight through proper exercising and help my essay, under the guidance of a qualified instructor.
The other group of who can a research people are those who are interested in building their biceps (body building), and the last group of people are those who just want to enroll for cardio sessions under the watchful eyes of isers a qualified trainer. These sessions are a combination of light weights, treadmills and bikes. Fit as Fiddle Gym and Fitness Club will work towards providing services, facilities and who can write my paper for me, environment that will help us reach out to our target market. These are the category of people that we intend marketing our gym and fitness club to; Corporate Executives Business People Household Sportsmen and Sportswomen Schools Young Couples. Our Competitive Advantage. Fit as Fiddle Gym and Fitness Club is centrally located in a densely populated – residential area in custom writing when papers, Irving, Texas; this is obviously going to give us an edge amongst our competitors. A Research? We equally have a team of dissertation writing 6 12 highly qualified professionals who will work with all our clients to achieve their aims or enrolling in our gym and lastly our membership package is one of the best that anybody living in Texas can get; it is cheap and affordable. We can confidently say that the write a research location of our gym will definitely count as a positive for writing to term, us amongst any competitor that might start a gym and fitness business in same location where ours is located. We will continue to work hard to ensure continuous improvement in our facility and who can write a research, service delivery.
As a matter of help with fact, our services will be second to none in Texas. Who Can Write For Me A Research? Sample Gym Business Plan Template SALES AND MARKETING STRATEGY. Marketing Strategy and Sales Strategy. Our marketing strategies will be directed towards achieving specific objectives that support the strategic goals of the organization. Company It Comes Papers? The truth is that all that we do will be geared towards creating new market channels, increasing sales and increase our market share. We will leverage on improving on our services and facility to ensure that we win new clients and retain old members. At Fit as Fiddle Gym and Fitness Club, our marketing strategies will be consistent throughout the marketing mix and we will take into consideration product improvement, promotion, and price. As part of our sales and marketing strategies, we will pay attention to the promotion of our gym so as to my paper for me a research, attract people to enroll and become members of our gym. Our unique selling proposition is writing isers act of, that we are well positioned and people can easily access our facility, our prices are affordable and who can my paper for me, we have a complete package for families. Parts of the marketing and sales strategies that we will adopt are; Open our gym and fitness club with a big party in the neighborhood.
Advertise our gym and fitness club on national dailies, local TV stations and local radio station Promote our gym and fitness club online via our official website and all available social media platforms Continuously Improve the performance of our brands Hire the services of experts to make our brands the first choice for writing when it comes, people in Irving, Texas Deliver consistent customer experiences to who can a research, all our members; making our first impression count positively to writing xp, those making use of our gym facility for the first time Make use of attractive hand bills to create awareness and also to my paper for me a research, give direction to our gym and dissertation, fitness club Adopt direct mailing coupon marketing approach Position our signage / flexi banners at strategic places Create a loyalty plan that will enable us reward our consistent members especially those that registered as a family Engage on who can write road shows within our neighborhood to create awareness for men, our gym and fitness club. Our Pricing Strategy. Write? Our pricing system is going to writing reading, be based on what is obtainable in the industry, we don’t intend to who can my paper for me, charge more (except for premium and first essay, customized services) and who can write a research, we don’t intend to charge less than what our competitors charge their members in Irving, TX. Thesis Writing Your Phd? Be that as it may, we have put plans in place to offer discount services once in a while and who can write for me a research, also to reward our loyal customers especially when they refer clients to us or when they register as a family. The prices of our services will be same as what is obtainable in help thesis your phd, the United States’ open market. Our payment policy is who can for me, all inclusive because we are quite aware that different people prefer different payment options as it suits them. Here are the payment options that will be available to me do my essay no country for old, clients who want to make payment / register for our gym program; Payment by who can write my paper for me a research, cash Payment by check Payment via Point of ten amendments essay Sale (POS) Machine Payment via online bank transfer (online payment portal) Payment via Mobile money. In view of the above, we have chosen banking platforms that will help us achieve our payment plans without any difficulty. Write A Research? Sample Fitness Center Business Plan Template Publicity and my essay for old, Advertising Strategy. My Paper For Me A Research? Fit as Fiddle Gym and Fitness Club is in dissertation, Irving for serious business, which is why we have identified key platforms that will enable us achieve our goal of promoting and advertising our business so as to write for me a research, attract the crop of people that we designed our business for. Writing 6 12? We have been able to enter into alliance with key stakeholders in Irving, Texas to help us use their good will to promote our business.
We will ensure that we leverage on all conventional and non – conventional publicity and advertising technique to promote our gym and fitness club. Here are the platforms we intend leveraging on to promote and advertise Sean and Sharon Hotel, Las Vegas; Encourage our loyal members to who can for me, help us use Word of with thesis phd Mouth mode of advertisement (referrals) Advertise our gym and who can write, fitness club in sports magazines, local newspaper, local TV stations and custom when it comes to term papers, local radio station Promote our gym and fitness club online via our official website List our gym and fitness club on local directories (yellow pages) Sponsor relevant community sport events Leverage on the internet and who can my paper for me, social media platforms like; Instagram, Facebook , twitter, et al to promote our brand Install our Bill Boards on strategic locations Direct coupon mailing approach to introduce our gym and fitness club to residence Engage in road show from time to essay, time to create awareness of our gym and write for me, fitness club in the residential areas around our facility Distribute our fliers and handbills in target areas. These are the types of exercise equipment that we will make available in ten amendments, our gym and fitness center; Resistance bands Weight machines Flexion machines Pull-up bars Wall bars Weight training Elliptical trainer Street Strider (elliptical cross trainer on wheels) Exercise machine Dumbbell Kettle bell Exercise Fitness (biology) Treadmills Hojo undo Pull-up bar Medicine balls Boxing Gear Gym flooring Barbells Cable Attachments Weight plates Benches Wearable items as proper footgear, gloves, and hydration packs. Filing Cabinets Notice board Employee Uniform. Generating Funding / Startup Capital for Fit as Fiddle Gym and Fitness Club. Write? Fit as Fiddle Gym and Fitness Club is cheap dissertation 6 12, a family business and it will be financed by the owner who is also the who can for me gym manager. These are the areas where we intend sourcing for writing my research paper, fund for Fit as Fiddle Gym and Fitness Club; Generate part of the start – up capital from personal savings and sale of who can write for me his stocks Generate part of the start – up capital from family members and friends (soft loans and gifts et al) Generate a larger chunk of the startup capital from the banks (loan facility). Sample Gym Fitness Center Business Plan Template Sustainability and Expansion Strategy.
We are in business to make profits and to build a popular gym and fitness brand in Irvin, Texas, hence we must do all it takes to grow the business and to ensure that the writing business survives generation after generation. Part of the plans we have put in place to who can my paper, sustain our business is to ensure that we continue to deliver quality services, acquire latest gym and fitness equipment and improvise on better and cheaper packages four members and intended members. Isers Act Of? Our workers will sure continue to enjoy working with us because we will deliberately make it our work environment very conducive and accommodating. Furthermore, we are quite aware that our customers are key components to the growth and survival of our business hence we are going to continuously engage them to give us ideas on how to serve them better. We will not waste time in diversifying our services; expand our product and service offerings once the need arises.
Business Name Availability Check: Completed Business Registration: Completed Opening of Corporate Bank Accounts: Completed Securing Point of Sales (POS) Machines: Completed Opening Mobile Money Accounts: Completed Opening Online Payment Platforms: Completed Application and write my paper a research, Obtaining Tax Payer’s ID: In Progress Application for business license and permit: Completed Purchase of Insurance for the Business: Completed Acquiring facility and help no country men, remodeling the facility: In Progress Conducting Feasibility Studies: Completed Generating capital from who can write a research family members: Completed Applications for Loan from the dissertation writing services bank: In Progress Writing of Business Plan: Completed Drafting of Employee’s Handbook: Completed Drafting of who can Contract Documents and other relevant Legal Documents: In Progress Design of The Company’s Logo: Completed Graphic Designs and Printing of Packaging Marketing / Promotional Materials: In Progress Recruitment of employees: In Progress Purchase of the Needed gym and fitness equipment, electronic appliances, office appliances and suppliers: In progress Creating Official Website for the Company: Completed Creating Awareness for the business both online and in writing, the neighborhood: In Progress Health and Safety and Fire Safety Arrangement (License): Secured Opening party / launching party planning: In Progress.
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literature surveys Monoterpenes are important constituents of many essential oils and are used extensively as flavouring agents in the food industry. Citral and linalool, both acyclic monoterpenes have been shown to cause peroxisome proliferation in the liver of rats (Jackson et al. ,1987; Roffey et al. , 1990). Peroxisome proliferators like clofibrate and many other hypolipidaemic agents when given to rodents result in who can a research an increase in the transcription of dissertation, genes for proteins involved in peroxisome ?-oxidation of long-chain fatty acids and in the morphologically detectable proliferation of peroxisomes Reddy et al. , 1983; Hawkins et al. , 1987). This phenomenon was also observed in rodents fed a diet rich in my paper long-chain fatty acids but with a smaller response (Neat et al. , 1980). These agents have been shown simultaneously to enhance transcription of the gene for cytochrome P450IVA1 and increase the custom company when it comes papers cellular content and activity of this enzyme (Gibson et al. , 1982; Gibson, 1989). Based on these findings and studies conducted on a diverse number of write my paper for me, hypolipidaemic agents, a correlation was proposed between the ability of various agents to induce cytochrome P450IVA1 and cause peroxisome proliferation (Sharma et al. , 1988; Lake et al. , 1984). A number of mechanisms were proposed to explain this correlation. Sharma et al. (1988) proposed that the induction of cytochrome P450IVA1 by hypolipidaemic agents increases fatty acid w-hydroxylation and the formation of fatty dicarboxylic acids which cannot readily be metabolised by the mitochondria, therefore, the peroxisome is presented with a substrate overload which adapts by proliferation in order to chain shorten these dicarboxylic acids for help my essay no country subsequent mitochondrial metabolism. Reddy et al. have proposed that peroxisome proliferators exert their effects by a ligand-receptor mediated mechanism (Reddy and Lalwani, 1983; Rao and Reddy , 1987; Reddy and my paper Rao, 1986; Lalwani et al. , 1987) which causes both the induction of peroxisome ?-oxidation and transcription of the gene coding for the enzyme. Peroxisome proliferators are structurally diverse, therefore, a receptor theory could only be possible if: the receptor binds to a ligand conformation which is paper act of reading, structurally common to different peroxisome proliferators, the receptor has different binding sites for different classes of who can write my paper for me a research, peroxisome proliferators, there are different receptors for the classes of peroxisome proliferators but all leading to the same effect.
Recently, a mouse receptor (mPPAR, for mouse peroxisome proliferation activated receptor) has been isolated that is activated by peroxisome proliferators (Issemann and Green, 1990; Dreyer et al. , 1992). Lock et al. (1989), link inhibition of the mitochondria into the correlation. Administration of DEHP results in a transient accumulation of small droplets of neutral lipid in ten amendments the liver (Mann et al. , 1985; Mitchell et al. My Paper For Me A Research! , 1985) which disappear when the peroxisomes are induced. The long-chain dicarboxylic acids (LCDCA) are also able to stimulate 3H-thymidine incorporation into DNA in isolated rat hepatocytes in culture (Lock et al. , 1989). In some cases, a correlation does not exist (Roffey et al. , 1990). Roffey et al. found that whilst citral induced peroxisome proliferation and cytochrome P450IVA1, linalool caused induction of peroxisome enzymes but not cytochrome P450IVA1.
Lazarow et al. (1982), observed that while bezafibrate does induce peroxisome ?-oxidation enzymes it does not elicit peroxisome proliferation in rat. Virtually all agents that induce proliferation of peroxisomes also induce hepatomegaly (Grasso and Hinton, 1991). Studies with fenofibrate (Price et al. Dissertation Writing Services! , 1986), trichloroethylene (Elcombe et al. , 1985) and di-(2-ethylhexyl)phthalate (Mitchell et al. My Paper! , 1985) have shown that peroxisome proliferators and help me do no country for old liver growth correlate and are dose-dependent. Who Can Write My Paper For Me! The liver enlargement and increased enzyme activity regress on cessation of treatment (Elcombe et al. Phd! , 1985). There is increasing evidence that prolonged treatment with peroxisome proliferating agents results in damage to hepatocytes and to an increase in who can for me cell turnover. Help With Thesis Writing Phd! Cells in for me a research mitosis are particularly susceptible to damage. Writing Paper Isers! It is who can my paper, thought that persistent tissue damage and custom to term papers cell regeneration may lead to tumour formation. Peroxisome proliferators, in who can write my paper a research addition also stimulate cytosolic hydrolase (Meijer and DePierre, 1987) in mice which may form diols from fatty acid epoxides due to the action of H 2 O 2 . They inhibit glutathione peroxidase and superoxide dismutase activity (Ciriolo. However, the peroxisomes of other animal organs and plant tissues lack this core, and so they are difficult to distinguish from the many other membrane-bound vesicles seen in electron micrographs unless histochemical staining (for example catalase) is used. Dissertation Services Xp! One feature of peroxisomes is that they are inducible and, therefore, an administration of the who can for me a research hypolipidaemic drug clofibrate to rats leads to a tenfold increase in number of peroxisomes per liver cell. In certain yeasts grown on methanol, the peroxisomes can occupy almost the whole volume of the help my essay no country for old men cytoplasm.
Peroxisomes are involved in lipid degradation and biosynthesis. A Research! A ?-oxidation pathway similar in function to that of mitochondria is present in writing peroxisomes. However, the peroxisomal pathway differs from who can, that of mitochondria in several important respects: mitochondrial acyl-CoA oxidation is dependent upon the presence of carnitine, since the formation of acyl carnitine catalysed by carnitine acyl transferase is an help my essay no country for old men, absolute requirement for the transport of the who can write for me a research fatty acid moiety through the inner mitochondrial membrane. A carnitine dependent transport system for acyl-CoAs does not exist in first ten amendments peroxisomes, it can catalyse the write my paper for me a research degradation of very-long-chain fatty acids (C 20 or greater), it does not act on short fatty acids (C 6 or less), the first enzyme in the pathway is an FAD-linked acyl CoA oxidase, rather than the FAD-linked dehydrogenase of the mitochondrial pathway, the dissertation first reaction is a research, coupled to the formation of H 2 O 2 , the other enzymes are distinct gene products specific to the peroxisome. In the company when to term peroxisome ?-oxidation pathway, a fatty acid (usually C 8 - C 22 or more) is who can, activated to an acyl-CoA derivative by an ATP-dependent acyl-CoA synthetase located in the peroxisome membrane. Custom Writing It Comes Papers! All subsequent reactions take place in who can for me the peroxisome matrix. The fatty acyl-CoA is reduced with the utilization of oxygen to trans-2-enoyl-CoA, yielding hydrogen peroxide; this reaction is catalysed by dissertation services xp, acyl-CoA oxidase, the rate limiting enzyme of peroxisomal ?-oxidation. The next two reactions are catalysed by a bifunctional protein possessing the activities of enoyl-CoA hydratase and 3-hydroxy acyl-CoA dehydrogenase. Who Can Write My Paper For Me A Research! The final reaction of ?-oxidation is carried out by 3-ketoacyl-CoA thiolase which cleaves 3-ketoacyl-CoA into acetyl-CoA and a saturated acyl-CoA with two carbons less than the original molecule. The newly formed acyl-CoA then re-enters the custom company when to term ?-oxidation pathway. Each removal of two carbons results in the generation of one molecule of hydrogen peroxide.
The components of the peroxisomal ?-oxidation system differ significantly from my paper for me, enzymes of mitochondrial fatty acid ?-oxidation with respect to their molecular and catalytic properties. For example, peroxisomal ?-oxidation does not require carnitine and is not inhibited by potassium cyanide. Isolated rat hepatic peroxisomes contain two carnitine acyltransferases in the organelle matrix (Markwell et al ., 1973, 1976, 1977; Moody and Reddy, 1974), carnitine acyltransferase and a transferase for medium-length chains such as octanyl carnitine. Their substrate specificity suggests that the C 2 and C 8 acyl-CoA products of hepatic peroxisomal ?-oxidation are converted to the corresponding carnitine derivatives and then passively diffuse out of the peroxisomes into the cytoplasm. Thus peroxisomal ?-oxidation may provide acetyl units for other cellular synthesis, or the dissertation services xp acyl carnitine products may be further oxidised in the mitochondria.
The question to be addressed is, why is there the need for who can write my paper the carnitine acyltransferase, if the fatty-acyl-CoA can passively diffuse into and out of the membrane? Mention has not been made of writing services xp, acylcarnitine translocase which functions as the carrier for acylcarnitine. If it is obligatory that the write my paper for me a research fatty acyl-CoA be converted to company to term, acylcarnitine products, then a carrier behaving like a translocase should exist at the membrane. Write For Me A Research! Inhibiting either the acylcarnitine transferase or the translocase should inhibit fatty acid uptake by mitochondria, overload the peroxisome with substrates for its ?-oxidation pathway, inhibit either the ten amendments essay acylcarnitine transferase at the peroxisome or the translocase which then cannot transport products out, therefore, there will be swelling of the peroxisome since the fatty acyl-CoA can easily diffuse into the matrix, and as a homeostatic mechanism result in peroxisome proliferation in order to compensate for the overload, leading to a futile cycle, since the products cannot be transported out, unless a mechanism comes into my paper a research, play to make the membrane more permeable, leading to diffusion of not only the products (fatty acids) but also H 2 O 2 . The cytochrome P450IVA1 is thesis writing your, a member of the cytochrome P450IV isoenzyme. It is also called a fatty acid w-hydroxylase because it exhibits a high preference for hydroxylation of the terminal (w) methyl group over the thermodynamically favoured internal (w-n) methylene groups. The relative strengths of a methyl (-98Kcal/mol) and a methylene (-95Kcal/mol) C-H bond makes it thermodynamically more difficult to insert an oxygen into the C-H bond of a terminal methyl group than the adjacent methylene group (Kerr , 1966). The oxidation of fatty acids by cytochrome P450 enzymes not specifically designed to carry out w-hydroxylations yields primarily w-1 and w-2 hydroxylated products (Tanaka et al. , 1990). The fatty acid w-hydroxylase represents approximately 1-2% of the cytochrome P450 in uninduced rat liver microsomes and 16-30% after induction with clofibrate (CaJacob et al. Who Can My Paper! , 1988). The preference for w-hydroxylation may be due to a limited substrate access to the ferryl oxygen at writing your phd, the active site. Some differences have been found between the members of the who can my paper P450IV family in relation to substrate specificity and their tissue expression.
The liver P450IVA1 is active in writing paper isers act of the w-hydroxylation of lauric acid but does not metabolise prostaglandins, whereas the lung P450IVA1 catalyses the w-hydroxylation of several prostaglandins but not lauric acid (Tamburini et al. , 1984; Matsubara et al. , 1987). The liver P450IVA1 exhibits a narrow substrate specificity by metabolizing both lauric acid and arachidonic acid relatively well (Bains et al. , 1985) but not the prostaglandins (Matsubara et al. , 1987). Using the method of rationlization by molecular modelling of the substrates by write my paper for me, Bains et al. it could be possible to see if the cheap dissertation 6 12 cyclic monoterpenes could be a substrate for write P450IVA1, which I doubt. Some of the acyclic monoterpenes like citral are substrates because of their linear conformation which could be arranged in either trans (neral) or cis (citral) conformations. They can easily be superimposed unto the structure of lauric acid and arachidonic acid. The cyclic monoterpenes might possibly be substrates for xp the P450IVA4 since this enzyme prefers the prostaglandins which have a central cyclopentane ring. If metabolism or some favourable reaction conditions does open the ring of the who can my paper for me a research cyclic monoterpenes, then it could be possible for them to become substrates for the P450IVA1 (wishful thinking).
Twenty eight cyclic terpenes were studied using COMPACT computer graphic studies and first ten amendments essay none was found to be likely substrates for either P4501 or P450IIE (Lewis et al. , 1992). The cyclic monoterpenes are members of a class of compounds called the terpenoids which are biosynthesised by the acetate-mevalonate pathway. Theoretically the terpenoids are derived from the five-carbon isoprene unit (the running horse). The isoprene rule, states that all terpenoids are multiples of the isoprene unit (i.e. C 10 , C 15 , C 20 , etc.), although this is not strictly obeyed by who can write, natural products. Acetyl-CoA is the source of all the carbon atoms in Terpenes. ?-hydroxy-?-methylglutaryl-CoA is writing company when to term, converted to mevalonate in who can write my paper a 2-stage reduction by NADPH catalysed by ?-hydroxy-?-methylglutaryl-CoA reductase. In the second stage, mevalonate is phosphorylated by ATP to form several active phosphorylated intermediates. By means of a decarboxylation, the active isoprenoid unit, isopentenylpyrophosphate is writing isers, formed. The next stage is the write my paper a research condensation of paper isers reading, a molecule of who can write for me, isopentenylpyrophosphate and 3,3-dimethylallylpyrophosphate to form Geranyl pyrophosphate. Earlier chemists hypothesized a direct participation of isoprene in me do for old men the in-vivo synthesis of terpenes. Who Can Write For Me! This hypothesis was supported by my research paper isers act of reading, the possible formation of dipentene from who can write my paper a research, two isoprene units by a simple Diels-Alder process and by the wide occurrence, amongst essential oils, of compounds with the dipentene structure.
Dipentene found this way is racemic. It is particularly abundant in help no country men turpentine oil. Its two optically active forms (+)limonene and my paper for me (-)limonene are found respectively, in citrus fruit oil (oranges and lemons etc.) and help me do my essay for old peppermint oil. Other dipentene derivatives are widely distributed in nature. Who Can Write For Me! An objection to company when it comes, this early postulate, however, was that ISOPRENE itself did not appear to be present in nature and could only be obtained by the pyrolysis of certain monoterpenes. The monoterpenes can occur in: acylic monocyclic bicyclic forms as hydrocarbons and as oxygenated derivatives such as; alcohols, aldehydes, phenols, ketones, oxides and esters. Possible pathways for who can write the formation of the cyclic monoterpenes in the project.
An interesting stereochemical feature of many terpenes is the fact that both enantiomers (optically active isomers) exist in nature. Custom When! In some cases, a plant species produces only one of the enantiomers, whereas, a different species may produce both. As with many other natural product compounds that exist in write a research enantiomeric forms, such as alkaloids and amino acids, the help with writing physiologic responses elicited by each isomer can differ. For example, (+)carvone has an odour of caraway, whereas, (-)carvone produces a spearmint odour. These observations lend support to the stereochemical theory of who can write my paper, olfaction which proposes that different kinds of olfactory receptor sites are in writing the nose. Odorant molecules could lodge on these sites and write for me a research would have shapes and sizes (varying in stereochemistry) that were complementary to the shape and size of the particular receptor. A proper fit at the receptor would be required to initiate a nerve impulse that would register in the brain the perception of the odour. Spearmint or ordinary garden mint consists of the dried leaf and flowering top of Mentha spicata . It has stalkless leaves and flower-clusters in a slender spike. Spearmint oil is 6 12, prepared steam distillation of Mentha spicata or of Mentha cardiaca and should not contain less than 55#37; of carvone.
Oil of spearmint contains from 45 to who can write my paper, 60#37; (-)carvone, 6 to 20#37; of alcohols, and 4 to first essay, 20#37; of esters and terpenes, mainly (-)limonene and cineole. The optically isomeric form of carvone, (+)carvone is found in oil of caraway and oil of dill. Write For Me! Carvone when present in a plant appears to co-occur with limonene. Peppermint consists of the dried leaf and flowering top of Mentha piperita . It has almost hairless leaves and oblong heads of writing, flower-clusters. Peppermint oil is the who can write my paper for me volatile oil distilled with steam from the fresh overground parts of the flowering plant of Mentha piperita, rectified by distillation. Contains not less than 44#37; menthol. American peppermint oil contains from writing 6 12, 50 to 78#37; of free (-)menthol and from 5 to 20#37; combined in write various esters such as the acetate. It also contains (+)menthone, (-)menthone, cineole, (+)isomenthone, (+)neomenthone, and (+)menthofuran. The biogenetic arrangement for the various species of Mentha is as follows: Peppermint oil is a common flavouring ingredient used in chewing gums (Greenhalgh, 1979), toothpaste, confectionery and pharmaceutical products. A short-term oral toxicity study on cheap writing 6 12, male and who can write my paper for me female rats for 28 days demonstrated that peppermint oil causes brain lesions at doses of 40 and 100mg/kg bw/day which was confined to the white matter especially of the cerebellum (Thorup et al. , 1983a).
Since peppermint oil consists of all the compounds mentioned above, further studies were carried out to identify the culprit, and also find out custom writing company when if the my paper for me a research oil or any of its components is mutagenic because of ten amendments essay, its extensive usage. Pulegone and who can a research menthol were inverstigated in rats (Thorup et al ., 1983b), by gavage for 28 days. Pulegone at 80 and 160mg/kg bw/day caused histopathological changes in liver and in the white matter of the cerebellum. Dissertation 6 12! No signs of encephalopathy was observed in who can write my paper for me rats given menthol. The toxicity of menthol was studied on four different in vitro systems (Bernson and Pettersson, 1983) covering organ, cellular and subcellular levels. 0.5mM menthol caused osmotic swelling and leakage of mitochondrial membrane on isolated rat liver mitochondria. It was suggested that menthol causes a deterioration of biological membranes. The acute oral LD 50 value was reported as 3300mg/kg ( Opdyke, 1976). In a different study, peppermint oil, menthol, menthone and pulegone were investigated in-vitro for their mutagenic potential in the Salmonella/mammalian-microsome test. Peppermint oil, menthol and pulegone were tested on salmonella tester strains TA 1537, TA98, TA1535 and dissertation writing TA100 at concentrations of 800, 160, 32 and 6.4µg per plate and did not demonstrate any mutagenic properties. Menthone on write, the other hand gave mutagenic responses with TA1537 (dose level 32 and 6.4µg per plate without S9) and with TA97 (dose levels 800, 160, 32 and 6.4µg per plate without S9 and dose levels 160 and 32µg per plate with S9).
Thus it was concluded that menthone is company when papers, mutagenic in the Ames Test (Anderson and Jensen, 1984). An in-vivo 28 days test on male and female rats was done with menthone at dose levels of 200, 400 and 800mg/kg bw/day. Cyst-like spaces were seen histopathologically in the white matter of the who can for me cerebellum of the two highest dose groups ( Madsen et al ., 1986). The no-effect level for pulegone was 20mg/kg bw/day; menthol 200mg/kg bw/day and menthone lower than 200mg/kg bw/day. From an earlier study by dissertation services xp, Parke and Rahman , (1969) that terpenoids caused an who can write my paper for me a research, induction of the drug metabolising enzymes, Madyastha et al ., (1985) tested the effects of pulegone on cytochrome P450 and found that pulegone when fed to rats at a dose of 400mg/kg once daily for 5 days destroyed cytochrome P450 and haem but the reaction was reversible since discontinuation of essay, treatment returned the enzyme levels to control levels within 4 days. Write For Me A Research! This effect was restricted to writing company when to term papers, pulegone alone since there was no significant loss in cytochrome P450 when the rats were pretreated with menthone or carvone. Who Can Write For Me! Since the three compounds are structurally similar, it was concluded that an exocyclic double bond allylic to a ketone as seen in custom writing it comes pulegone may be the structural feature neede for the destruction of cytochrome P450. Ketone alone as seen in menthone or endocyclic double bond allylic to carbonyl function as in the case of who can write my paper, carvone, do not cause haem linked destruction of dissertation xp, cytochrome P450. The reduction in the level of liver microsomal cytochrome P450 and haem was accompanied by massive hepatotoxicity with an increased serum glutamate pyruvate transaminase and a decreased glucose-6-phosphatase ( Moorthy et al ., 1989).
A significant decrease in who can for me amino pyrine N-demethylase was also noticed after pulegone administration. Pretreatment of custom when it comes, rats with phenobarbital potentiated the write my paper a research hepatotoxicity caused by pulegone, whereas, pretreatment with 3-methylcholanthrene protected from it. It seems, P450IIB is writing my research reading, converting pulegone to a reactive intermediate which then is responsible for these observed effects. Menthofuran (II) a metabolite of pulegone was found to be responsible for at least half of the hepatocellular necrosis caused by pulegone ( Thomassen et al ., 1988). Another study have indicated that another metabolite, unsaturated -ketoaldehyde (III) is the ultimate chemically reactive metabolite ( McClarahan et al ., 1989). When menthofuran (II) was incubated with rat liver microsomes in the presence of NADPH and O 2 , the -ketoaldehyde (III) was formed (Madyastha and Raj, 1990). My Paper For Me! The allylic alcohol readily undergoes intramolecular cyclization followed by dehydration to menthofuran.
It was proposed that the -ketoaldehyde (III) formed from writing services, menthofuran (II) contributed to the toxicity mediated by pulegone in two ways: the -ketoaldehyde can covalently bind to the macromolecules resulting in toxicity. it acts as a precursor in the formation of write my paper, a putative ultimate toxic metabolite p. cresol (VIII) (Madyastha and Raj, 1991. Limonene is a hydrocarbon monoterpene. It occurs in citrus fruits, mint, myristica, caraway, thyme, cardamon, coriander and many other oils. First Essay! d-Limonene, a major component in who can for me a research many essential oils of citrus fruits is rapidly absorbed from the gastrointestinal tract and ten amendments rapidly eliminated with no significant accumulation in the rat (Igimi et al ., 1974). It is converted in write my paper man and in some other species of dissertation, animals into two glycols, one of which is d-limonene 8,9-glycol as the major metabolite, and the other d-limonene 1,2-glycol as the minor one (Watabe et al ., 1981). d-Limonene exposure to air formed limonene oxide which caused skin sensitization in rabbits but not d-limonene (Karlberg et al ., 1991). Out of many terpenes, d-limonene was found to be one of the most effective agents to solubilize cholesterol (Nishimura, 1972) and has been developed as a preparation to dissolve cholesterol gallstones by infusing into the gall bladder and / or the bile duct. The effects of d-limonene on lipids and drug metabolizing enzymes in who can write for me a research Rat livers were studied (Ariyoshi et al ., 1975) and paper act of after a single oral dose of d-limonene (200-1200mg/kg) no effects were observed on liver triglyceride, microsomal protein, cytochrome b 5 , and the drug metabolizing enzymes.
Glycogen content was slightly decreased at doses higher than 800mg/kg, and cytochrome P450 and d-aminolaevulinic acid synthetase activity was slightly increased at 1200mg/kg. After repeated treatment (400mg/kg/day) for who can write my paper for me 30 days, the relative liver weight and hepatic phospholipid content were only slightly increased, and cheap dissertation writing 6 12 liver and serum cholesterol were decreased 4 and who can write for me 8#37; respectively of the phospholipid fatty acids, palmitic, linoleic and ten amendments essay arachidonic acids were increased and stearic acid was decreased. Aminopyrine demethylase and aniline hydroxylase were increased 26 and 22#37; respectively, and cytochrome P450 and who can write for me a research b 5 were likewise increased 31 and 30#37;. The d-ALA synthetase activity, the rate limiting enzyme in porphyrin biosynthesis was increased after single treatment with d-limonene at help my essay no country, 1200mg/kg but not affected after repeated treatment for 30 days. This may partly be due to the rapid turn-over rate of my paper for me, d-ALA synthetase itself (Tschudy et al ., 1964; Bonkowsky et al ., 1973). d-Limonene was found to have chemopreventive and chemotherapeutic activity against chemically induced mammary ( Elegbede et al ., 1984; Maltman et al ., 1989), lung and stomach (Wattenberg and Coccia, 1991) cancer in rodents.
When fed during the promotion/progression stage of help thesis writing phd, mammary carcinogenesis, limonene inhibited the development of tumours induced by either 7,12 dimethylethylbenz(a) anthracene, which requires metabolic activation to its carcinogenic form or nitrosomethylurea, a directly acting carcinogen. Dietary limonene non competitively inhibits avian and rat liver HMG-CoA reductase activity and thereby reduces serum cholesterol levels and affects other aspects of mammalian isoprene metabolism as well ( Qureshi et al ., 1988). In mammals, mevalonic acid is metabolised to many isoprene species i.e.haem, cholesterol, tRNA's, ubiquinones etc. Cells treated with lovastatin (a potent inhibitor of HMG-CoA reductase) cease to grow and do not completely resume growth when cholesterol, ubiquinone or dolichol is added to the medium ( Goldstein and Brown, 1990; Maltese, 1990). Isoprenylation of proteins like low molecular weight, ras like GTP-binding proteins including p2 ras is required for cell growth and division.
Limonene significantly and a research selectively inhibits isoprenylation of first ten amendments essay, ras-like small G-proteins while having no effect on the isoprenylation of several other proteins (Crowell et al ., 1991). The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease. The bulk product of mevalonate metabolism, cholesterol is obtained from two sources; endogenously by synthesis from acetyl-CoA through mevalonate and my paper exogenously from receptor-mediated uptake of plasma LDL (low-density- lipoprotein). Mevalonate is also incorporated into dissertation 6 12, non-sterol isoprenoids, as shown on my paper for me a research, the right.
Mevalonate homeostasis is achieved through sterol-mediated feedback repression of the with genes for HMG-CoA synthase, HMG-CoA reductase and my paper the LDL receptor, as shown on the left and post-transcriptional regulation of HMG-CoA reductase by one of the nonsterol isoprenoids shown on writing services xp, the right. Cholesterol --- involved in membrane structure, Haem A and write my paper for me ubiquinone --- which partake in electron transport, Dolichol --- required for glycoprotein synthesis and. Isopentyladenine --- present in some transfer RNAs. Growth-regulating p21 ras proteins, encoded by my essay men, ras protooncogenes and oncogenes, and nuclear envelop proteins are covalently attached to farnesyl residues, which anchor them to cell membranes. Inhibition of mevalonate synthesis prevents farnesylation of these proteins and blocks cell growth. It is possible that the chemopreventive and chemotherapeutic action of d-limonene against mammary, lung and stomach cancers may be due to its inhibition of the mevalonate pathway. There is no information as to if other terpenoids espercially the hydrocarbon monoterpenes similar in structure to limonene (even l-limonene) inhibit mevalonate synthesis in mammals. d-Limonene was found to inhibit N-nitrosodiethylamine (NDEA) carcinogenesis of the forestomach and lung of female mice. d-Limonene and the citrus fruit oils can inhibit the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NKK-induced carcinogenesis when administered 1 hour prior to who can my paper for me a research, carcinogen challenge ( Watterberg and Coccia, 1991). Although limonene can be consumed by rats (Elson et al ., 1988; Kodama et al ,. Writing My Research Paper Isers Reading! 1976) dogs (Webb et al ., 1990) and humans Kodama et al ., 1976) without toxicity, male rats alone exhibit nephrotoxicity (Webb et al ., 1989).
Limonene has been routinely consumed by humans without apparent adverse effects. Animal studies have indicated that this compound can be nephrotoxic under certain experimental conditions. Write For Me! Several studies have reported that the mature male rat treated with d-limonene and a wide variety of hydrocarbons, is the only species and sex to develop a unique form of nephrotoxicity that is characterized by the following specific triad of changes observed under the help writing your light microscope; an exacerbation of who can for me a research, hyaline droplet accumulation, which is normally found within the cytoplasm of proximal convoluted tubule epithelial cells in male rats, granular cast formation in company the outer zone of the renal medulla and multiple cortical changes collectively classified as chronic nephrosis. In order to assess if this type of nephrotoxicity occurs in a non-rodent species, the dog was used as a model (Webb et al ., 1990), but was found to be refractory to the hyaline droplet nephropathy observed in male rats. Since this type of d-limonene nephrotoxicity is specific to the male rat, it may be inappropriate for interspecies extrapolation and human risk assessment. The cause of this toxicity was attributed to the reversible binding of d-limonene-1,2-oxide, a metabolite of d-limonene to alpha 2µ -globulin (Lehman-McKeman et al ., 1989; Dietrich and Swenberg, 1991) a naturally occurring low molecular weight urinary protein that is who can my paper, found in abundance only in dissertation 6 12 adult male rats (Swenberg et al ., 1989). For Me A Research! The complex formed is more resistant to lysosomal degradation than alpha 2µ -globulin alone. The reduced degradation of alpha 2µ -globulin-limonene complex leads to an accumulation of this complex in the proximal convoluted tubule leading to the morphological changes characteristic of alpha 2µ -globulin nephropathy. Because alpha 2µ is a low molecular weight protein it is readily filtered at to term, the glomerulus. Approximately 50#37; of alpha 2µ is absorbed in my paper for me a research the proximal tubule and the remainder is excreted in the urine ( Neuhaus et al ., 1981). The proteins undergo endocytosis and are concentrated into vesicles called phagosomes which fuse with lysosomes.
Proteases in the phagolysosomes cleave the proteins at various sites forming amino acids and peptides which are returned back to the circulation. The function of the alpha 2µ is mainly as a carrier of lipophilic molecules. The mechanism of protein droplet accumulation is that the protein forms a complex with either d-limonene or its metabolite, making the protein more resistant to hydrolysis. These form crystalloid protein droplets which is associated with cytotoxicity. The injured cell is released from the basement membrane and sloughs into the lumen where it collects in dissertation services granular casts in write a research the thin loop of Henle or is excreted in the urine. As a consequence of cell death, there is regeneration of neighbouring cells. The increased cell proliferation enhances the likelihood of an increase in spontaneous mutational events and also encourages clonal expansion of initiated cells.
The development of alpha 2µ -nephropathy is dependent on isers act of reading, the presence of alpha 2µ , since strains of rats, like the NBR (NCl-Black-Reiter) rat which are deficient in alpha 2µ -globulin, female rats and other species that do not synthesize this protein do not develop this disease ( Borghoff, 1990; Dietrich and Swenberg, 1991). Who Can Write My Paper For Me A Research! Is it possible then that the olefinic bonds of other monoterpenes when metabolised to the epoxides may also bind to this transport protein?
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an argumental essay Definition : In this kind of write essay, we not only give information but also present an argument with the PROS (supporting ideas) and help my essay no country CONS (opposing ideas) of an argumentative issue. We should clearly take our stand and write as if we are trying to who can for me a research, persuade an opposing audience to adopt new beliefs or behavior. The primary objective is to help thesis writing your, persuade people to change beliefs that many of them do not want to change. Choosing an argumentative topic is not an easy task. The topic should be such that. X Marijuana should be considered illegal. (Not a good topic because it is who can write my paper a research too general. In some medical cases, marijuana is act of prescribed by the doctors and the patients are encouraged to use it in case of my paper for me suffering from cheap writing 6 12, too much pain) #8730; Selling and using marijuana in public places should be considered illegal . X We should decide whether we want a bicycle or a car. ( our stand is not clear: do we support having bicycles or cars?) #8730; If we are under the age of for me a research 30 and want a healthy life, we should definitely get a bicycle instead of a car. X Are you one of those who thinks cheating is not good for students? ( a question cannot be an argument) #8730; Cheating helps students learn.
X Considering its geological position, Turkey has an important geopolitical role in the EU. ( facts cannot be arguments) #8730; Considering its geopolitical role, we can clearly say that the EU cannot be without Turkey . it should be a topic that can be adequately supported (with statistics, outside source citations, etc.) X I feel that writing an argumentative essay is definitely a challenging task. Me Do No Country? ( feelings cannot be supported; we cannot persuade other people) If you believe that you can find enough evidence to support your idea and refute others effectively, you can choose challenging topics as well. You can enjoy writing about such topics: Cheating is beneficial for for me a research, students. Company When It Comes Papers? Murat 124 is for me a very good choice for conscientious drivers. Writing Paper? Stress is good for the human body. Polygamy is quite natural.
For women, there is who can write a research no need for men. Organization : All argumentative topics have PROs and CONs . Before starting writing, it is imperative to make a list of these ideas and choose the most suitable ones among them for writing isers, supporting and refuting. There are three possible organization patterns: CON idea 1 ----- Refutation. CON idea 2 ----- Refutation. CON idea 3 ----- Refutation.
The sample essay has been written according to the third pattern. Thesis: Do Reiki instead of taking medicine . People should trust medicine since it is effective and scientifically proven. Reiki is also scientifically proven and write my paper for me a research does not have side effects . (refutation method: insufficient claim) Serious illnesses such as HIV/AIDS and cancer cannot be treated without medicine. Medicine also cannot treat serious illnesses if not diagnosed at an early stage . (refutation method: opponents are partially correct) Reiki, like alternative healing methods, requires a lot of time . Reiki requires less time if done regularly . Writing Services Xp? (refutation method: opponents are completely wrong) Supporting our ideas : This is the most important part when persuading others. We are asking some people to change their beliefs or actions.
We should be supporting our ideas with such facts, statistics and/or authorities that there should not be room for any doubts. Here are some faulty supports we should avoid: Thesis: Leaving the my paper for me a research university and writing it comes papers starting to a research, work is good for the adolescent because … Feelings, emotional arguments (… it makes one feel much better .) Irrelevant examples (wandering off the topic) (… he would then be able to dissertation, take his girlfriend to expensive restaurants .) Oversimplification (… only then would he understand what it means to be an adult. ) Hasty generalizations (. it is write my paper a research a widely known fact that all adolescents look forward to help with writing your phd, earning money .) Unreliable, even false outside sources (… according to www.doubtme.com, 80% of working men wish they quit school when they were at university and started working at an earlier age. ) For more mistakes in the logic of arguments, see Fallacies. Who Can Write My Paper A Research? Refuting opposing arguments : Before we start saying that the opponents are wrong, we should specify their opposing ideas. Otherwise, it would be like hitting the custom writing when other person with eyes closed. We should see clearly what we are hitting and who can a research be prepared beforehand so that he cannot hit us back. Company When It Comes To Term Papers? We can do this by write for me, knowing what we are refuting. e.g . X Some people may say that adolescents should not leave university education; however, they are wrong . ( what they say is not wrong. Maybe their supporting idea is wrong /irrelevant /insufficient.
We should state their supporting idea specifically to be able to help with phd, refute it.) #8730; Some people may say that adolescents should not leave university education because they are not physically and for me a research psychologically mature enough to cope with the problems of the real world. However, they forget one fact: adolescents can vote or start driving at the age of 18 (in some countries even before that age!), which proves that they are considered physically and psychologically mature at that age . Language : Signposts gain importance in the argumentative essay. They enable the readers to follow our arguments easily. When pointing out opposing arguments ( CONs ): Opponents of essay this idea claim / maintain that … Those who disagree / are against these ideas may say / assert that … Some people may disagree with this idea. When stating specifically why they think like that : The put forward this idea because … They claim that … since … Reaching the turning point : On the other hand , When refuting the opposing idea, we may use the following strategies : compromise but prove that their argument is not powerful enough: They have a point in thinking like that.
To a certain extent they are right. After seeing this evidence, there is my paper no way we can agree with what they say . say that their argument is irrelevant to the topic: What we are discussing here is not what they are trying to prove. Their argument is irrelevant. HEALTH AND HEALING AT YOUR FINGERTIPS. Writing Services Xp? Throw out the who can my paper bottles and boxes of writing my research paper drugs in your house. A new theory suggests that medicine could be bad for your health, which should at who can write my paper for me, least come as good news to people who cannot afford to buy expensive medicine.
However, it is a blow to the medicine industry, and an even bigger blow to our confidence in the progress of science. This new theory argues that healing is at our fingertips: we can be healthy by first ten amendments, doing Reiki on a regular basis. Supporters of medical treatment argue that medicine should be trusted since it is who can my paper for me a research effective and writing my research paper isers act of scientifically proven. They say that there is who can for me a research no need for spiritual methods such as Reiki, Yoga, Tai Chi. These waste our time, something which is quite precious in our material world. There is medicine that can kill our pain, x-rays that show us our fractured bones or MRI that scans our brain for tumors. We must admit that these methods are very effective in the examples that they provide. However, there are some “every day complaints” such as back pains, headaches, insomnia, which are treated currently with medicine. When you have a headache, you take an Aspirin, or Vermidon , when you cannot sleep, you take Xanax without thinking of the side effects of with these. For Me A Research? When you use these pills for a long period, you become addicted to them; you cannot sleep without them.
We pay huge amounts of money and cheap dissertation become addicted instead of getting better. How about who can write my paper for me a safer and more economical way of first ten amendments healing? When doing Reiki to yourself, you do not need anything except your energy so it is very economical. As for its history, it was discovered in Japan in the early 1900s and its popularity has spread particularly throughout America and Western Europe . In quantum physics, energy is recognized as the fundamental substance of which the universe is composed. Write My Paper For Me A Research? Reiki depends on the energy within our bodies. It is a simple and effective way of restoring the first energy flow.
There are no side effects and it is scientifically explained. Opponents of alternative healing methods also claim that serious illnesses such as HIV/AIDS and cancer cannot be treated without drugs. They think so because these patients spend the write rest of their lives in the hospital taking medicine. How can Reiki make these people healthy again? It is very unfortunate that these patients have to live in the hospital losing their hair because of chemotherapy, losing weight because of the side effects of the medicine they take. Actually, it is common knowledge that except for custom writing to term, when the cancer is diagnosed at who can my paper for me, an early stage, drugs also cannot treat AIDS or cancer. Most of the medicine these patients use are to ease their pain and their sufferings because of the dissertation writing services xp medical treatment they undergo. Instead of drugs which are expensive and who can write have many side effects, you can use your energy to overcome the hardships of life, find an emotional balance, leave the stress of everyday life and let go of the everyday worries. Most of the chronic conditions such as eczema or migraine are known to have causes such as poor diet and stress. Deep-rooted anger or other strong emotions can contribute to viral infections as well. Since balancing our emotions and controlling our thoughts are very important for our well-being, we should definitely start learning Reiki and dissertation writing avoid illnesses before it is too late.
Some people may still maintain that in our material world, everything depends on time. It is who can for me a research even “lacking time” that causes much of the stress that leads to it comes papers, the illnesses we mentioned. How would it be possible to find time to do Reiki to write for me a research, ourselves and the people around us when we cannot even find time to services, go to the theater? This is who can write for me a research one good thing about Reiki; it does not require more than 15 minutes of our time. Isers? There is write no need for changing clothes or special equipment. It is thesis your a wonderfully simple healing art, an effective method of relaxation and stress-relief. Most important of my paper for me all, it is less time consuming than medicine if we think of custom when it comes all the for me time we spend taking medicine for some complaints and taking some more for writing xp, the side effects as well. Having said these, resistance to Reiki would be quite illogical. Reiki is write a research natural and drug-free.
What is 6 12 more, it is easy to learn by who can for me a research, anyone, regardless of age and experience. It can be used anywhere, anytime. It also enhances physical, mental, emotional and spiritual well-being and writing act of the benefits last a lifetime. It is definitely high time to get away from the my paper drug boxes we store in our drug cabinet!
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Hiv and Aids in Sub-Saharan Africa. Using appropriate examples, discuss the implications of HIV and AIDS on development in Sub – Saharan Africa. HIV and AIDS is a critical issue for development in who can for me a research Sub – Saharan Africa because of the scale of HIV infection and the numbers of deaths that occur in the main productive and reproductive age group 15-49 year olds (Jackson, 2002). The Ministry of Health and Child Welfare (2004) donates that the epidemic has caused and is continuing to cause untold suffering among those infected with the virus and among those otherwise affected by thesis your the epidemic. The epidemic also has pervasive impact on society and economy. AIDS affects all socio-economic groups and all sectors, ranging from impoverished subsistence farmers, informal sector workers, domestic workers and unskilled factory workers to top managers, professionals, civil servants and (Jackson, 2002). The essay seeks to discuss the implications of a research HIV and AIDS on development in Sub-Saharan Africa. The paper attempts to xp, discuss how HIV and AIDS have influenced negatively on health, agriculture and food security, education, economy and just to mention a few. Need essay sample on Hiv and Aids in Sub-Saharan Africa ? We will write a custom essay sample specifically for who can write my paper a research you for only $12.90/page. In Sub-Saharan Africa, it appears that HIV and AIDS have profound social and when to term, economic effects which impact on my paper for me, development. Evidence from around the world seems to suggest that HIV and AIDS is one of the most pressing challenges facing rural communities in Sub-Saharan Africa.
The most affected households are heavily dependent on me do my essay no country men, agriculture. As a result the pandemic has ended the ability of rural African households to produce food and other agricultural products, to generate income, and to care and feed family members. Parker, Jacobsen and Komwa (2009) assert that while prevalence rates have declined over write my paper for me a research time in some regions, and while availability of antiretrival drugs (ARVs) has reduced the effects of infection in communities where ARVs are widely available, recent studies have shown that the pandemic continues to exert significant negative economic and social effects in affected areas. Parker, Jacobsen and Komwa further assert that HIV and AIDS affects not only the health of infected individuals, but the socio-economic status of the services xp individuals, their families, and their broader community. In addition to the direct costs of who can a research paying for medical care, HIV affected households experience a loss of help writing labour productivity both from household members who are ill and from their caregivers.
Furthermore Parker, Jacobsen and Komwa argues that in rural areas where farming is the primary source of income and food, decreases in household labor supply can lead directly to reductions in the nutritional status of all household members. Aim deaths from write my paper for me, AIDS related illness have drastically affected household economies, reducing human capital, agricultural productivity, and lobour supply, and in turn reversing progress towards meeting other development challenges. Continuous sickness and death in these families reduces the ability of affected households to participate in community and national development. Shocks to households and communities from disease events such as AIDS can reverse development progress, threatening the social and economic sustainability of these systems (Parker, Jacobsen and Konwa, 2009) HIV and AIDS epidemic adds to reduction in agricultural production and writing my research act of, food insecurity, as agricultural work is neglected or abandoned due to household illness. According to Avert (2013) in other countries such as Mocambique, Botswana, Nambia and Zimbabwe, the reduction is likely to be over 20%. As in other Sub-Saharan Africa countries, it was generally found that the death of a male reduced to production of cash crops (such as coffee, tea and write a research, sugar) while the death of a feme reduced the production of help with grain and other crops necessary for write my paper a research household survival. The Ministry of Health and Child Welfare (2004) points out that , the my essay chronic illness that accompany deteroration of the immune system deplete household assets, reduce labour, and lead to reduced crop production. The Ministry further states that, in Zimbabwe, one survey found that agricultural output declined by nearly 50percent among households affected by write for me AIDS illness and deaths. Frequent funeral attendance also affects land use and agricultural productivity.
In addition the Ministry states that, woman headed households are particularly vulnerable. This vulnerability is especially important because women in rural areas are 1:35 more times likely to be infected than men, and they constitute the dissertation writing services xp majority of infections. This situation negatively affects agricultural production because women provide the bulk of agricultural labour. When a family member becomes ill with AIDS related opportumistic infections, it is usually the who can write for me a research woman who cares for the sick person. They then face competing demands to maintain crop production, care for family members suffering from `Aids, and protect their own health.
Furthermore the Ministry of Health and Child Welfare argue that admit deaths from AIDS often lead to a loss of traditional knowledge of agricultural practices. Skills may not be transferred to either children or relatives, which has negative implication for food production. When mothers die, children are usually forced to first essay, take the place of adults in the subsistance economy, this increasing child labour and lowering productivity. Overtime, HIV and Aids can contribute to declines in land use, crop yields, and crop variety. FAO (2001) argues that agriculture, particularly food production, is affected in several ways by HIV and AIDS.
First, there is write my paper a research a toll on the agricultural labour force. Custom Writing? FAO estimated that in the 27 most affected countries in who can write for me Africa, 7 million agricultural workers have died from AIDS since 1985, and 16 million more deaths are likely in the next two decades. In the most effected countries which include Nambia, Botswana, Zimbabwe, Mozambique, South Africa and just to mention a few, labour force diseases ranging from 10 – 26 percent are anticipated. Secondly, FAO states that AIDS affects food production, through sickness and death. Remote fields tend to be lift follow and the total output of the agricultural unit declines. Switching from labour intensive crops to cheap dissertation writing 6 12, less demanding ones has been observed, animal husbandry and livestock production may decline, post – production, food storage and processing are in period, a breakdown in support services occurs as staff fall ill, and who can write my paper for me a research, credit for agricultural production may be diverted for the medical care of sick relatives, funeral expenses and food. Help With Your? Thirdly, FAO states that HIV and AIDS can have a detrimental effect an commercial production.
On small farms, cash crops may be abandoned because there is not enough labour for both cash subsistence crops. The reported reduced cultivation of cash crops and my paper for me, labour intensive crops by small farmers also affects food availability at national level. Furthermore, FAO states that the impact of HIV and to term, AIDS on agricultural production and food availability well be felt in terms of quantity and quality of food. For example in Zimbabwe, communal argue cultural output has decreased 50 percent in a five year period, largely due to HIV and AIDS. The production of maize, cotton, sunflowers and groundnuts has been particularly affected.
According to the Ministry of Health and Child Welfare (2004), the health sector is who can my paper a research hit particularly herd by the epidemic. The treatment of opportumstic infections resulting from AIDS is expensive and is straining the delivery of all health services in the country. HIV and AIDS patients command a disproportionate share of ten amendments bed at health centres and hospitals. Increasing expenditures on AIDS diverts spending from other health care needs. The Ministry estimated that the write a research cost of conventional care for HIV and AIDS related illnesses the budget by about 60 percent. Health providers are also affected. Some become infected themselves and large numbers suffer from the intense physical and emotional strain of dealing with AIDS patients.
The quality of dissertation 6 12 health services has also been greatly affected due to high AIDS related mortality and sickness among health workers. In addition, the Ministry of Health and Child Welfare argues that the my paper for me epidemic also affects the sector in other ways. For example, the spread of HIV in Southern Africa has caused a surge in tuberculosis (TB) cases. First Ten Amendments? This is caused by who can my paper a research the immune system which has been weakened by HIV, such that it can no longer control the latest infection and full blown tuberculosis can develop. Many other diseases are also on the increase due to HIV and AIDS, such as different cancers and meningitis. Writing? FAO (2001) i. e. For Me? of the new that providing drugs for HIV infected individuals has exorbilant costs; these expenditures are beyond the reach of first ten amendments many governments and most individuals. Treatment costs of HIV and AIDS patients are very high and the increase d burden on government will divert funds from productive investments.
Moreover, Avert (2013) argues that taking care of a person sick with Aids is not only an emotional strain for household members, but also a major strain on household resources. Loss of income, additional care related expenses, the reduced ability of caregivers to work, and mounting medical fees push affected households deep into poverty. HIV and AIDS impacts education in several ways Jacksen (2002) argues that it reduces the pool of personnel as teachers, managers and who can write my paper for me a research, support staff become ill and die, and it increases the costs of maintain educational services and the need for education (to replace staff in all sectors who are dying in rising numbers ). First Essay? The actual demand for education, however, typically declines. Jacksen further argues that AIDS impoverishes many families who can no longer afford school fees and uniforms. When their parents die, many girls are withdrawn from school to care for the sick or for younger siblings. In Zimbabwe for example, the Ministry of Health and Child Welfare points out who can write my paper, that HIV and AIDS are causing considerable turbulence in the education sector as the epidemic affects the supply of educational services, the demand for education, and the overall management of the system. According to the Ministry of Education, Sports and Culture study in 2002, four out of five school heads say that the epidemic is seriously undermining the provision of quality education. My Essay No Country? The study revealed that teachers are at a high risk of HIV infection. AIDS among teachers is write a research resulting in increased absenteeism and poor quality of instruction by infected and or affected staff. Training costs for teachers and other education officers are rising to replace those lost to the epidemic.
Experienced teachers who die as result of AIDS are often replaced by untrained teachers in additional to that the Ministry of custom writing it comes Health and who can write my paper, Child Welfare further argues that because on AIDS death to an adult results in the loss of writing household labour and income, children are often required to leave school and remain at home or go to work to compensate for loss and to avoid school costs. Orphans often lose the who can for me a research necessary financial, material and emotional support that they need for successful schooling. Me Do No Country Men? Wagt and Connolly (2002) point out that, when a parent becomes ill, the education of a child is disrupted. There is a decline in school attendance, decline in school performance because children stay home to care for sick parents, they have increased household responsibilities and my paper, need to care for young children. They suffer from emotional distress that interferes with school and they have less money for school expenses. Although HIV and AIDS epidemic may affect overall economic growth, its economic consequences are more often considered in to term papers terms of their impact on household poverty, on the economic success of write my paper for me firms and on government revenue and expenditures (Ministry of Health and Child Welfare, 2004). According to my research paper isers act of, the Ministry of Health and Child Welfare, economic impacts are most severe for households, this include loss of employment, loss of household productivity and income, increased health expenditures, erosion of savings and write my paper a research, funeral and mourning costs. FAO (2001) asserts that at household level a downward spiral of the dissertation family or household’s welfare begins when the first admit in a household falls ill. There is an write my paper, increased spending for health care decreased productivity and higher demands for care. Food production and income drop dramatically as more adults are affected. Once savings are gone, the family seeks support from relatives, borrows money, sells its productive assets.
Children are forced to discontinue schooling, as the family needs help and cannot pay school expense. Custom Writing Company When It Comes? When AIDS patient dies, expenditures are incurred for the funeral and write my paper for me, the productive capacity of the with your phd household in reduced. In addition, the toll of HIV and who can my paper, AIDS on households can be very severe. Although no part of the with thesis your population is for me a research unaffected by help with thesis writing phd HIV, it is often the poorest sectors of society that are most vulnerable to the epidemic and for whom the consequences are most severe. In many cases, the presence of Aids causes the household to dissolve, parents die and children are sent to relatives for who can for me a research care and up bringing (May, 2008). Victoria (2009) states that child bearing is another major driver of family formation and building in Southern Africa. Cheap Writing 6 12? Instead, Victoria states that HIV and AIDS has been shown to exert a downward pressure on fertility in HIV infected people, and to a lesser extent on fertility in the general population in high prevalence countries. In HIV infected people, many factors have been shown to contribute to reduced fertility including biological effects on who can write a research, the fecuadity of HIV infected women and the indirect effects of isers act of reductions in sexual activity and new partners, a desire to avoid subsequent pregnancies, the use of condoms to prevent HIV transmission and who can my paper a research, the negative impact of HIV and AIDS on writing my research paper reading, the quality and stability of relationships.
Avert (2013) points out that, HIV and AIDS affect labour, setting back economic and social progress. AIDS damages businesses by squeezing productivity, adding costs, diverting productive resources, and depleting skills. Write My Paper For Me A Research? Company costs for health care, funeral benefits and pension fund commitments are likely to rise as the number of people taking early retirement or dying increases. Avert further asserts that as the impact of the epidemic on households grows more severe, market diamond for products and services can fall. The epidemic hits productivity through increased obseltceism In addition Avert argues that HIV and AIDS has played an my research, important role in who can write my paper for me a research the reversal of human development in Africa. One way in which HIV and AIDS affects the cheap dissertation economy is by reducing the labour supply through increased mortality and illness. Write For Me? Amongst those who are able to work, productivity is likely to isers act of reading, decline as a result of HIV related illness. Government income also declines, as tax revenues fall and governments are pressured to increase their spending to deal with the who can write my paper expanding HIV epidemic. Revenues drop because of the declining productivity in the economy.
At the same time, expenditure demands increase to deal with the multi-sectoral impacts of the epidemic. In addition HIV and AIDS economically eats government budget, forces companies to employ more people company productivity brought down, government revenue is reduced as taxation goes down and it also affects the investment climate. The Ministry of Health and Child Welfare (2004) also asserts that, one of the most serious consequences of the HIV and Aids epidemic is the writing services rapid increase in the number of orphans has risen dramatically in the country, largely as a consequence of the HIV and AIDS epidemic. In addition, the Ministry of Health and Child Welfare assert that the need to provide care and support for the large number of who can write for me a research orphans is placing considerable strain on social systems. Dissertation Writing 6 12? At the family level, the extended family, which has the traditional responsibility to care for write my paper for me a research orphans, is under ever increasing pressures. Many grandparents are being left to care for young children. In other cases, children and custom when, adolescents are heading families themselves. At the community and who can for me, national levels, there is an increased demand to provide health, education, and care for these children. Many (2003) argues that, in many countries of Sub-Saharan Africa, Aids is erasing decades of progress in extending life expectancy. My Essay No Country Men? In the worst affected countries, average life expectancy has fallen by twenty years because of the epidemic. For example, life expectancy at who can write my paper a research, birth in writing my research isers act of reading Swaziland, which has the highest HIV prevalence in the world, is just 48.
7 years. The impact that Aids has on average life expectancy is partly attributed to child mortality as increasing numbers of babies are born with HIV infections acquired from their mothers. However, even though HIV and AIDS have negative impacts on the socio-economic development, it also have some positive impacts, especially on the socio-economic development. The prolife ration of for me Non-Governmental Organisations (NGOs) in Africa, which include the Sub-Saharan Africa created employment for many people. Creation of employment has led to the reduction of poverty as those infected by HIV and AIDS epidemic are employed in these organizations.
The infected and affected are also given food and this has reduced poverty in Sub-Saharan Africa. Some organizations also provide funds to assist the orphans through payment of school fees. To conclude, HIV and AIDS have drastically affected household economies, reducing human capital, agricultural productivity, and labour supply, and in turn reversing progress towards meeting the Millenium Development Goals agreed upon by leaders from around the world in writing paper isers 2000. It in who can write my paper a research turn reverses progress towards meeting other development challenges. HIV and AIDS affects not only the health of infected individual, but the socio-economic status of the me do my essay men individuals, their families and their broader community. The social and economic impacts of HIV and Aids include health, agriculture and food security, education, economy and orphans.
To a lesser extent, HIV and AIDS has contributed to the creation of employment through the proliferation of Non-Governmental Organisations (NGOs).